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A Transcriptional Signature and Common Gene Networks link Cancer with Lipid metabolism and Diverse Human Diseases 0comments
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  • published in 2010-04-12 20:34:00 
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  • Publication year: 2010Source: Cancer Cell Volume 17 Issue 4 13 April 2010 Pages 348-361Heather A. Hirsch Dimitrios Iliopoulos Amita Joshi Yong Zhang Savina A. Jaeger ...Transcriptional profi ...
  • Publication year: 2010
    Source: Cancer Cell Volume 17 Issue 4 13 April 2010 Pages 348-361
    Heather A. Hirsch Dimitrios Iliopoulos Amita Joshi Yong Zhang Savina A. Jaeger ...
    Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unexpectedly lipid metabolism genes are important for transformation and are upregulated in cancer tissues. As in atherosclerosis oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-魏B leading to transformation. OLR1 is important for maintaining the transformed state in developmentally diverse cancer cell lines and for tumor growth suggesting a molecular connection between cancer and atherosclerosis. We...
    Graphical abstract聽Highlights:聽鈻?A transcriptional signature links cancer to inflammatory and metabolic diseases 鈻?Drugs used to treat diabetes and cardiovascular disease inhibit tumor growth 鈻?Lipid metabolism genes and oxidized LDL receptor (OLR1) have oncogenic functions 鈻?OLR1 activation of the inflammatory pathway connects cancer with atherosclerosis
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